Njengamanje, kunezinhlobo ezingaba ngu-81 zemithi elwa nesimila evame ukusetshenziswa emtholampilo.1. Izidakamizwa ezilwa nesimila zihlukaniswa ngokuya ngomthombo wazo nendlela yokwenza.Ngokuvamile ihlukaniswe izidakamizwa alkylating, antimetabolites, antibiotics, izitshalo, amahomoni kanye nezinye izidakamizwa.Eminye imithi ihlanganisa i-platinum, i-asparaginase, imithi yokwelapha eqondiwe, njll., ngaphandle kwama-reagents e-biological kanye nokwelashwa kwezakhi zofuzo.Lesi sigaba asikwazi ukufingqa ukuthuthukiswa kwamanje kwezidakamizwa ezilwa nesimila.Okwesibili, okunye ukuhlukaniswa kusekelwe ekuhlosweni kwamangqamuzana ezidakamizwa, ezihlukaniswe izigaba eziningi.Isigaba sokuqala yizidakamizwa ezisebenza esakhiweni samakhemikhali se-DNA, njenge-alkylating noma i-platinum compounds.Isigaba sesibili izidakamizwa ezithinta i-nucleic acid synthesis, njenge-antimetabolites.Isigaba sesithathu isidakamizwa esisebenza kusifanekiso se-DNA, sithinta ukulotshwa nokuvinjelwa kwe-DNA, futhi sinqande ukuhlanganiswa kwe-RNA ngokuthembela ku-RNA polymerase.Isigaba sesine yizidakamizwa ezithinta i-protein synthesis, njenge-paclitaxel, i-vinblastine njalonjalo.Isigaba sokugcina ezinye izinhlobo zezidakamizwa, njengama-hormone, i-aspartic acid, izidakamizwa ezihlosiwe zokwelashwa, njll., kodwa izidakamizwa zamanje zokulwa nesimila zikhula ngokushesha, futhi izigaba ezingenhla azikwazi ukufingqa izidakamizwa ezikhona kanye nezidakamizwa ezimayelana ukungena emtholampilo..“

Njengamanje, kunezidakamizwa eziningi ezilwa nesimila emisebenzini yomtholampilo.Ngokwesibonelo,i-oxaliplatin, i-fluorouracil, futhi i-irinotecan ingasetshenziselwa izimila zamathumbu.Iziguli ezinomdlavuza wesisu zingelashwa ngezidakamizwa ezifanai-cisplatinfuthipaclitaxel.Ngokuvamile, izinhlobo zomdlavuza zikhetha imithi ehlukene.Ngaphezu kwalokho, iziguli ezinomdlavuza zingelashwa nangezidakamizwa ezihlosiwe zamangqamuzana, njenge-erlotinib, i-osimertinib, i-cetuximab nezinye izidakamizwa.

Izidakamizwa ezivamile zokulwa nesimila ezibangela i-CIPN zihlanganisaI-Paclitaxel, Platinum, Vinblastine,I-Methotrexatei-Fluorouracil, i-Ifosfamide,I-Cytarabine, i-Fludarabine, i-Thalidomide,I-Bortimiazolenjalo njalo.

I-Paclitaxel isebenzisa isici sokukhula kwezinzwa ukunciphisa noma ukubuyisela emuva ubuthi be-neurotoxicity;I-cisplatin isebenzisa i-glutathione encishisiwe ne-amifostine ukuvimbela i-neuropathy ebangelwa yiyo;I-oxaliplatin ayixhumani nokugqugquzelwa okubandayo ngesikhathi sokusetshenziswa ukuze kuvinjwe ukugqugquzelwa okubandayo ukuthi kungathinteki imizwa yangaphandle.i-ifosfamide ingakhetha i-methylene eluhlaza okwesibhakabhaka ukuvimbela ubuthi be-neurotoxicity;sebenzisa i-thiamine ye-fluorouracil ingase ivimbele izinzwa Umphumela wobuthi.